Transmural healing as a therapeutic goal in Crohn's disease: a systematic review

Transmural healing is associated with substantial improvements in disease-related outcomes for patients Crohn's disease, but there no single validated definition of transmural to date. We did a systematic review summarise the available definitions and evaluate effect on disease by searching PubMed, Cochrane Library, Web Science interventional non-interventional studies. Seventeen studies were included, reporting rates between 14·0% 42·4% patients. was assessed magnetic resonance enterography, bowel sonography, or CT enterography. Most used wall thickness, 3 mm less as most frequent cutoff, define healing. Vascularisation doppler ultrasound absence complications contrast enhancement also this definition. significantly outcomes. In addition, good correlation healing, mucosal selected biomarkers. conclude that thickness frequently item which long-term should be considered new treatment target.